MTA-SZTE Cortical Microcircuits Research Group
Principal investigator: Gábor Tamás
We have started to uncover the electrophysiological and morphological properties of human cortical cells. In the layer 1 we found GABAergic interneuron subtype human interneurons with anatomical features never described in rodents (Boldog et al, 2018). These cells have large ‘rosehip’-like axonal boutons and compact arborization and shows unique immunohistochemical profile. Continuing neural characterization of the human cortex we collecting data with different techniques in order to extract morphological, electrophysiological, ultrastructural and molecular features and dissimilarities to rodent neurons.
Uncovering the role of GABAergic micro network in diabetes could open therapies of dementia and early Alzheimer’s disease (recently referred as 3rd type diabetes). Previously we showed that cortical inhibitory cell called neurogliaform cell releases insulin (Molnár et al., 2014) and contains GLP-1 (glucagon like peptide) receptors (Csajbók et al., 2019).