More than twenty-five years ago, a research initiative on methane was launched in Szeged, opening entirely new perspectives on how inflammatory processes can be treated. Today, methane – once dismissed as an inert atmospheric bystander – is emerging as a surprising ally in the fight against inflammation. Building on this long-running work, Professor Dr. Mihály Boros and his team are now exploring methane’s biological effects in research that may reshape how we understand and treat inflammatory diseases. We spoke with Professor Boros about the discoveries emerging from their project, supported by HU-rizon, an international research-excellence program funded by Hungary’s National Research, Development and Innovation Office (NRDI Office).