Research group leader: Dr. József Kaszaki
The main research field of the research group is the investigation of the physiological and pathological regulation of the circulation by the application of clinically compatible animal models of human pathologies.
We perform our experiments in a two following research fields:
Sepsis research group:
Dr. József Kaszaki, Dr. Marietta Poles, Dr. László Juhász, Dr. Szabolcs Tallósy, Attila Rutai PhD student, Student: Roland Fejes
Research collaboration: Prof. Dr. Zsolt Molnár, Deparment of Anesthesiology and Intensive Therapy
Research project:
Sepsis remains one of the leading causes of death in the intensive care units all around the world without an effective and adequate therapy. The main problem of sepsis is the imbalance between oxygen the delivery and cellular oxygen consumption (oxygen dynamical disturbances), which require complex haemodynamical monitoring and blood gas analysis. Disturbance of the oxygen dynamics lead necessarily to irreversible oxygen extraction deficit and energy shortage of cells. The cornerstone of acute care should be to prevent, assess and treat oxygen debt globally, and both at the levels of macro- and microcirculation and the cellular level. With this theoretical background, the major goal of our study is to find optimal, clinically applicable manoeuvres for microcirculatory recruitment and mitochondrial resuscitation to minimize the energy deficit of organs during the septic response by (1) elimination and deactivation of sepsis-induced inflammatory cascade biomarkers, (2) treatments with combined endothelin A receptor antagonist - B receptor agonist, (3) endogenous and synthetic NMDA antagonists, or (4) complement C5a antagonist and (5) the use of glycocalyx-dependent, goal-directed fluid resuscitation strategies. In our experiments we apply a live bacterial flora-induced rodent and mini-pig models of sepsis (License number of experimentation: V/175/2018). We hope that these studies could lead us closer to understanding and treating the pathology of this severe, multiple organ failure associated condition.
